Crossword Puzzle Wrinkle-reducing shot

Clue: Wrinkle-reducing shot

Wrinkle-reducing treatment (BOTOX with 5 letters)
Shot up with Novocain (NUMB with 4 letters)
They're shot in rafts (RAPIDS with 6 letters)
Not the big shot (BBS with 3 letters)
Saying at the onset of wrinkles (Part 1) (TIMEMAYBEAGREAT with 15 letters)
Final shot (DEATHBLOW with 9 letters)
Take a shot (e.g. DARE with 4 letters)
Calls the shots (e.g. DIRECTS with 7 letters)
Mocking nickname for Dr. J, in reference to his mediocre jump shot? (NORANGEJULIUS with 13 letters)
Why some need a shot in the arm (FLU with 3 letters)